Pramipexole CAS NO.104632-26-0

1. Introduction of Pramipexole

Synonyms: Pramipexole
Fomular: C₁₀H₁₇N₃S
M.W.: 211.

1. Introduction of Pramipexole

Synonyms: Pramipexole
Fomular: C₁₀H₁₇N₃S
M.W.: 211.32
Feature: Similar white to slight yellow powder

Pramipexole (CAS NO.104632-26-0) is a similar white to slight yellow powder and can be used to manufacture the Antiparkinsonian drug. Our Pramipexole is NLT 99.0%(HPLC) and can be manufactured 5 metric ton per year. Besides, it is always in stock and can be sent from the beijing port. Whereas, we'd like to receive from the L/C or T/T.

Others:

Appearance: Similar white to slight yellow powder
Loss on drying: NMT 0.5%
Residue on ignition: NMT 0.5%
Heavy metals: NMT 20ppm
Assay: NLT 99.0%(HPLC)

Package: 25KG/NET Fiber Drum with double lined plastic bag inside
Packaging Details: Fiber Drum Size: diameter 350mm x height 500mm,tare weight: 2.8-2.9kg; PE bag: width 600mm x height 900mm xthickness 0.06mm



2. Basic information of Pramipexole

1) Properties:

(1)XLogP3-AA: 1.9; (2)H-Bond Donor: 2; (3)H-Bond Acceptor: 4; (4)Rotatable Bond Count: 3; (5)Tautomer Count: 2; (6)Exact Mass: 211.114319; (7)MonoIsotopic Mass: 211.114319; (8)Topological Polar Surface Area: 79.2; (9)Heavy Atom Count: 14; (10)Complexity: 188; (11)Defined Atom Stereocenter Count: 1; (12)Covalently-Bonded Unit Count: 1; (13)Feature 3D Donor Count: 2; (14)Feature 3D Cation Count: 2; (15)Feature 3D Hydrophobe Count: 1; (16)Feature 3D Ring Count: 2; (17)Effective Rotor Count: 3.8; (18)Conformer Sampling RMSD: 0.6.

2) Descriptors of Structure

InChI: InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1
InChIKey: FASDKYOPVNHBLU-ZETCQYMHSA-N
Canonical SMILES: CCCNC1CCC2=C(C1)SC(=N2)N
Isomeric SMILES: CCCN[C@H]1CCC2=C(C1)SC(=N2)N
IUPAC Name: (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

3) Production of Pramipexole

4-propylamino cyclohexyl ketone (I) bromide in acetic acid can react with hydrobromic acid. Then the outcome (II) blending with the thiourea and then acidified the outcome the get the Pramipexole (CAS NO.104632-26-0).



4) Usage

Pramipexole is a (S)-Pramipexole enantiomer. It can be used as a dopamine-D2-receptor agonist and to manufacture the Antiparkinsonian drug.

Used in the treatment of Parkinson's disease.